Fig. 8.
Effect of NO-O2− interactions on interstitial CNO (A) and CO2− (B) in each region. Concentrations are given for baseline conditions (black bars), in the absence of reaction between NO and O2− (white bars, “no reaction”), or if O2− generation were 10 times higher (grey bars, “O2− production × 10”). In the latter case, CO2− would be 10 times greater than in the base case. Results correspond to case C; as described in the text, in cases A and B the relative changes would be smaller for CNO, and identical for CO2−. The model predicts that O2− consumption by NO significantly reduces medullary CO2−, but that O2− has a small impact on medullary NO bioavailability under physiological conditions.