Table 1.

Effect of variations in generation rates on NO and O₂⁻ concentrations (in nM) at the mid-inner stripe

	CNO in R1	CNO in R2	CNO in R3	CNO in R4	CO2− in R1	CO2− in R2	CO2− in R3	CO2− in R4
Case A	104	63	43	57	0.109	0.049	0.010	0.009
Case B	104	63	42	56	0.142	0.119	0.045	0.020
Case C	104	62	42	56	0.213	0.179	0.067	0.030
10-Fold decrease in GNO	10.4	6.3	4.3	5.7	0.159	0.062	0.012	0.012
	10.4	6.3	4.3	5.6	0.207	0.150	0.055	0.027
	10.3	6.2	4.2	5.6	0.311	0.224	0.082	0.040
No capillary NO synthesis	104	59	39	55	0.109	0.050	0.010	0.009
	103	59	38	54	0.142	0.121	0.046	0.020
	103	58	38	53	0.213	0.182	0.069	0.030
10-Fold increase in GO2−	100	60	41	54	1.100	0.493	0.100	0.087
	98	54	34	48	1.445	1.223	0.465	0.206
	95	51	31	44	2.190	1.859	0.709	0.314
10-Fold decrease in GO2−	105	64	43	57	0.011	0.005	0.0009	0.0008
	105	64	43	57	0.014	0.012	0.0045	0.0020
	105	64	43	57	0.021	0.018	0.0067	0.0029
No capillary O2− synthesis	104	63	43	57	0.108	0.045	0.009	0.008
	104	63	42	56	0.142	0.113	0.043	0.019
	104	62	42	56	0.213	0.170	0.065	0.029
SOD concentration =10 μM in cells	105	64	43	57	0.009	0.003	0.0003	0.0003
	105	64	43	57	0.011	0.006	0.0013	0.0006
	105	64	43	57	0.017	0.010	0.0020	0.0009

In each set of simulations, results are shown for cases A, B, and C. Baseline values are in bold. NO, nitric oxide; O₂⁻, superoxide; C_NO and C_O2−, NO and O₂⁻ concentration, respectively; G_NO and G_O2−, NO and O₂⁻ generation, respectively. The rate of O₂⁻ synthesis is taken to either decrease with decreasing Po₂ (case A), to remain independent of Po₂ (case B), or to increase with decreasing Po₂ (case C).