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. 1994 Jun;93(6):2305–2310. doi: 10.1172/JCI117234

Paroxysmal nocturnal hemoglobinuria and the glycosylphosphatidylinositol anchor.

E T Yeh 1, W F Rosse 1
PMCID: PMC294434  PMID: 8200963

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  1. AUDITORE J. V., HARTMANN R. C., FLEXNER J. M., BALCHUM O. J. The erythrocyte acetylcholinesterase enzyme in paroxysmal nocturnal hemoglobinuria. Arch Pathol. 1960 May;69:534–543. [PubMed] [Google Scholar]
  2. Antony A. C. The biological chemistry of folate receptors. Blood. 1992 Jun 1;79(11):2807–2820. [PubMed] [Google Scholar]
  3. Armstrong C., Schubert J., Ueda E., Knez J. J., Gelperin D., Hirose S., Silber R., Hollan S., Schmidt R. E., Medof M. E. Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants. J Biol Chem. 1992 Dec 15;267(35):25347–25351. [PubMed] [Google Scholar]
  4. Aster R. H., Enright S. E. A platelet and granulocyte membrane defect in paroxysmal nocturnal hemoglobinuria: usefulness for the detection of platelet antibodies. J Clin Invest. 1969 Jul;48(7):1199–1210. doi: 10.1172/JCI106084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BECK W. S., VALENTINE W. N. Biochemical studies on leucocytes. II. Phosphatase activity in chronic lymphatic leucemia, acute leucemia, and miscellaneous hematologic conditions. J Lab Clin Med. 1951 Aug;38(2):245–253. [PubMed] [Google Scholar]
  6. Bessler M., Mason P. J., Hillmen P., Miyata T., Yamada N., Takeda J., Luzzatto L., Kinoshita T. Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene. EMBO J. 1994 Jan 1;13(1):110–117. doi: 10.1002/j.1460-2075.1994.tb06240.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bobolis K. A., Moulds J. J., Telen M. J. Isolation of the JMH antigen on a novel phosphatidylinositol-linked human membrane protein. Blood. 1992 Mar 15;79(6):1574–1581. [PubMed] [Google Scholar]
  8. Clark D. A., Butler S. A., Braren V., Hartmann R. C., Jenkins D. E., Jr The kidneys in paroxysmal nocturnal hemoglobinuria. Blood. 1981 Jan;57(1):83–89. [PubMed] [Google Scholar]
  9. Costello L. C., Orlean P. Inositol acylation of a potential glycosyl phosphoinositol anchor precursor from yeast requires acyl coenzyme A. J Biol Chem. 1992 Apr 25;267(12):8599–8603. [PubMed] [Google Scholar]
  10. Cross G. A. Glycolipid anchoring of plasma membrane proteins. Annu Rev Cell Biol. 1990;6:1–39. doi: 10.1146/annurev.cb.06.110190.000245. [DOI] [PubMed] [Google Scholar]
  11. DACIE J. V., LEWIS S. M. Paroxysmal nocturnal haemoglobinuria: variation in clinical severity and association with bone-marrow hypoplasia. Br J Haematol. 1961 Oct;7:442–457. doi: 10.1111/j.1365-2141.1961.tb00354.x. [DOI] [PubMed] [Google Scholar]
  12. Davitz M. A., Low M. G., Nussenzweig V. Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein. J Exp Med. 1986 May 1;163(5):1150–1161. doi: 10.1084/jem.163.5.1150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. DeGasperi R., Thomas L. J., Sugiyama E., Chang H. M., Beck P. J., Orlean P., Albright C., Waneck G., Sambrook J. F., Warren C. D. Correction of a defect in mammalian GPI anchor biosynthesis by a transfected yeast gene. Science. 1990 Nov 16;250(4983):988–991. doi: 10.1126/science.1978413. [DOI] [PubMed] [Google Scholar]
  14. Edberg J. C., Salmon J. E., Whitlow M., Kimberly R. P. Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins. J Clin Invest. 1991 Jan;87(1):58–67. doi: 10.1172/JCI115001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Englund P. T. The structure and biosynthesis of glycosyl phosphatidylinositol protein anchors. Annu Rev Biochem. 1993;62:121–138. doi: 10.1146/annurev.bi.62.070193.001005. [DOI] [PubMed] [Google Scholar]
  16. Ferguson M. A., Williams A. F. Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures. Annu Rev Biochem. 1988;57:285–320. doi: 10.1146/annurev.bi.57.070188.001441. [DOI] [PubMed] [Google Scholar]
  17. Ham T. H., Dingle J. H. STUDIES ON DESTRUCTION OF RED BLOOD CELLS. II. CHRONIC HEMOLYTIC ANEMIA WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: CERTAIN IMMUNOLOGICAL ASPECTS OF THE HEMOLYTIC MECHANISM WITH SPECIAL REFERENCE TO SERUM COMPLEMENT. J Clin Invest. 1939 Nov;18(6):657–672. doi: 10.1172/JCI101081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Hillmen P., Bessler M., Mason P. J., Watkins W. M., Luzzatto L. Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5272–5276. doi: 10.1073/pnas.90.11.5272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hirose S., Prince G. M., Sevlever D., Ravi L., Rosenberry T. L., Ueda E., Medof M. E. Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine. J Biol Chem. 1992 Aug 25;267(24):16968–16974. [PubMed] [Google Scholar]
  20. Holguin M. H., Fredrick L. R., Bernshaw N. J., Wilcox L. A., Parker C. J. Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria. J Clin Invest. 1989 Jul;84(1):7–17. doi: 10.1172/JCI114172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Holguin M. H., Wilcox L. A., Bernshaw N. J., Rosse W. F., Parker C. J. Relationship between the membrane inhibitor of reactive lysis and the erythrocyte phenotypes of paroxysmal nocturnal hemoglobinuria. J Clin Invest. 1989 Nov;84(5):1387–1394. doi: 10.1172/JCI114311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Homans S. W., Ferguson M. A., Dwek R. A., Rademacher T. W., Anand R., Williams A. F. Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein. Nature. 1988 May 19;333(6170):269–272. doi: 10.1038/333269a0. [DOI] [PubMed] [Google Scholar]
  23. Hyman R. Somatic genetic analysis of the expression of cell surface molecules. Trends Genet. 1988 Jan;4(1):5–8. doi: 10.1016/0168-9525(88)90120-5. [DOI] [PubMed] [Google Scholar]
  24. Hänsch G. M., Schönermark S., Roelcke D. Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9. J Clin Invest. 1987 Jul;80(1):7–12. doi: 10.1172/JCI113065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Ikezawa H., Yamanegi M., Taguchi R., Miyashita T., Ohyabu T. Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus. I. purification, properties and phosphatase-releasing activity. Biochim Biophys Acta. 1976 Nov 19;450(2):154–164. [PubMed] [Google Scholar]
  26. Inoue N., Kinoshita T., Orii T., Takeda J. Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy. J Biol Chem. 1993 Apr 5;268(10):6882–6885. [PubMed] [Google Scholar]
  27. Kamitani T., Chang H. M., Rollins C., Waneck G. L., Yeh E. T. Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone. J Biol Chem. 1993 Oct 5;268(28):20733–20736. [PubMed] [Google Scholar]
  28. Kamitani T., Menon A. K., Hallaq Y., Warren C. D., Yeh E. T. Complexity of ethanolamine phosphate addition in the biosynthesis of glycosylphosphatidylinositol anchors in mammalian cells. J Biol Chem. 1992 Dec 5;267(34):24611–24619. [PubMed] [Google Scholar]
  29. Kodukula K., Amthauer R., Cines D., Yeh E. T., Brink L., Thomas L. J., Udenfriend S. Biosynthesis of phosphatidylinositol-glycan (PI-G)-anchored membrane proteins in cell-free systems: PI-G is an obligatory cosubstrate for COOH-terminal processing of nascent proteins. Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4982–4985. doi: 10.1073/pnas.89.11.4982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Kunstling T. R., Rosse W. F. Erythrocyte acetylcholinesterase deficiency in paroxysmal nocturnal hemoglobinuria (PNH). A comparison of the complement-sensitive and insensitive populations. Blood. 1969 Apr;33(4):607–616. [PubMed] [Google Scholar]
  31. Lewis S. M., Dacie J. V. Neutrophil (leucocyte) alkaline phosphatase in paroxysmal nocturnal haemoglobinuria. Br J Haematol. 1965 Sep;11(5):549–556. doi: 10.1111/j.1365-2141.1965.tb00099.x. [DOI] [PubMed] [Google Scholar]
  32. Lisanti M. P., Sargiacomo M., Graeve L., Saltiel A. R., Rodriguez-Boulan E. Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithelial cell line. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9557–9561. doi: 10.1073/pnas.85.24.9557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Low M. G., Finean J. B. Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C. Biochem J. 1977 Oct 1;167(1):281–284. doi: 10.1042/bj1670281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Low M. G. Glycosyl-phosphatidylinositol: a versatile anchor for cell surface proteins. FASEB J. 1989 Mar;3(5):1600–1608. doi: 10.1096/fasebj.3.5.2522071. [DOI] [PubMed] [Google Scholar]
  35. Low M. G., Saltiel A. R. Structural and functional roles of glycosyl-phosphatidylinositol in membranes. Science. 1988 Jan 15;239(4837):268–275. doi: 10.1126/science.3276003. [DOI] [PubMed] [Google Scholar]
  36. Mahoney J. F., Urakaze M., Hall S., DeGasperi R., Chang H. M., Sugiyama E., Warren C. D., Borowitz M., Nicholson-Weller A., Rosse W. F. Defective glycosylphosphatidylinositol anchor synthesis in paroxysmal nocturnal hemoglobinuria granulocytes. Blood. 1992 Mar 15;79(6):1400–1403. [PubMed] [Google Scholar]
  37. Mayne K. M., Pulford K., Jones M., Micklem K., Nagel G., van der Schoot C. E., Mason D. Y. Antibody By114 is selective for the 90 kD PI-linked component of the CD66 antigen: a new reagent for the study of paroxysmal nocturnal haemoglobinuria. Br J Haematol. 1993 Jan;83(1):30–38. doi: 10.1111/j.1365-2141.1993.tb04627.x. [DOI] [PubMed] [Google Scholar]
  38. Medof M. E., Gottlieb A., Kinoshita T., Hall S., Silber R., Nussenzweig V., Rosse W. F. Relationship between decay accelerating factor deficiency, diminished acetylcholinesterase activity, and defective terminal complement pathway restriction in paroxysmal nocturnal hemoglobinuria erythrocytes. J Clin Invest. 1987 Jul;80(1):165–174. doi: 10.1172/JCI113043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Menon A. K., Eppinger M., Mayor S., Schwarz R. T. Phosphatidylethanolamine is the donor of the terminal phosphoethanolamine group in trypanosome glycosylphosphatidylinositols. EMBO J. 1993 May;12(5):1907–1914. doi: 10.1002/j.1460-2075.1993.tb05839.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Menon A. K., Stevens V. L. Phosphatidylethanolamine is the donor of the ethanolamine residue linking a glycosylphosphatidylinositol anchor to protein. J Biol Chem. 1992 Aug 5;267(22):15277–15280. [PubMed] [Google Scholar]
  41. Misumi Y., Ogata S., Ohkubo K., Hirose S., Ikehara Y. Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form. Eur J Biochem. 1990 Aug 17;191(3):563–569. doi: 10.1111/j.1432-1033.1990.tb19158.x. [DOI] [PubMed] [Google Scholar]
  42. Miyata T., Takeda J., Iida Y., Yamada N., Inoue N., Takahashi M., Maeda K., Kitani T., Kinoshita T. The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science. 1993 Feb 26;259(5099):1318–1320. doi: 10.1126/science.7680492. [DOI] [PubMed] [Google Scholar]
  43. Miyata T., Yamada N., Iida Y., Nishimura J., Takeda J., Kitani T., Kinoshita T. Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1994 Jan 27;330(4):249–255. doi: 10.1056/NEJM199401273300404. [DOI] [PubMed] [Google Scholar]
  44. Nagakura S., Kawaguchi T., Horikawa K., Hidaka M., Iwamoto N., Takatsuki K., Nakakuma H., Kagimoto T. A deficiency in CDw52 (CAMPATH-1 antigen) of paroxysmal nocturnal hemoglobinuria lymphocytes. Blood. 1993 Dec 15;82(12):3790–3792. [PubMed] [Google Scholar]
  45. Norris J., Hall S., Ware R. E., Kamitani T., Chang H. M., Yeh E., Rosse W. F. Glycosyl-phosphatidylinositol anchor synthesis in paroxysmal nocturnal hemoglobinuria: partial or complete defect in an early step. Blood. 1994 Feb 1;83(3):816–821. [PubMed] [Google Scholar]
  46. Orlean P., Albright C., Robbins P. W. Cloning and sequencing of the yeast gene for dolichol phosphate mannose synthase, an essential protein. J Biol Chem. 1988 Nov 25;263(33):17499–17507. [PubMed] [Google Scholar]
  47. Pangburn M. K., Schreiber R. D., Müller-Eberhard H. J. Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A. 1983 Sep;80(17):5430–5434. doi: 10.1073/pnas.80.17.5430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Pangburn M. K., Schreiber R. D., Müller-Eberhard H. J. Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria. Proc Natl Acad Sci U S A. 1983 Sep;80(17):5430–5434. doi: 10.1073/pnas.80.17.5430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Ploug M., Plesner T., Rønne E., Ellis V., Høyer-Hansen G., Hansen N. E., Danø K. The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria. Blood. 1992 Mar 15;79(6):1447–1455. [PubMed] [Google Scholar]
  50. Puoti A., Conzelmann A. Characterization of abnormal free glycophosphatidylinositols accumulating in mutant lymphoma cells of classes B, E, F, and H. J Biol Chem. 1993 Apr 5;268(10):7215–7224. [PubMed] [Google Scholar]
  51. Puoti A., Desponds C., Fankhauser C., Conzelmann A. Characterization of glycophospholipid intermediate in the biosynthesis of glycophosphatidylinositol anchors accumulating in the Thy-1-negative lymphoma line SIA-b. J Biol Chem. 1991 Nov 5;266(31):21051–21059. [PubMed] [Google Scholar]
  52. Roberts W. L., Myher J. J., Kuksis A., Low M. G., Rosenberry T. L. Lipid analysis of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase. Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C. J Biol Chem. 1988 Dec 15;263(35):18766–18775. [PubMed] [Google Scholar]
  53. Roberts W. L., Santikarn S., Reinhold V. N., Rosenberry T. L. Structural characterization of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase by fast atom bombardment mass spectrometry. J Biol Chem. 1988 Dec 15;263(35):18776–18784. [PubMed] [Google Scholar]
  54. Rosse W. F., Adams J. P., Thorpe A. M. The population of cells in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis: significance and mechanism of increased immune lysis. Br J Haematol. 1974 Oct;28(2):181–190. doi: 10.1111/j.1365-2141.1974.tb06652.x. [DOI] [PubMed] [Google Scholar]
  55. Rosse W. F., Hoffman S., Campbell M., Borowitz M., Moore J. O., Parker C. J. The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis. Br J Haematol. 1991 Sep;79(1):99–107. doi: 10.1111/j.1365-2141.1991.tb08014.x. [DOI] [PubMed] [Google Scholar]
  56. Rosse W. F., Parker C. J. Paroxysmal nocturnal haemoglobinuria. Clin Haematol. 1985 Feb;14(1):105–125. [PubMed] [Google Scholar]
  57. Rosse W. F. Phosphatidylinositol-linked proteins and paroxysmal nocturnal hemoglobinuria. Blood. 1990 Apr 15;75(8):1595–1601. [PubMed] [Google Scholar]
  58. Schubert J., Alvarado M., Uciechowski P., Zielinska-Skowronek M., Freund M., Vogt H., Schmidt R. E. Diagnosis of paroxysmal nocturnal haemoglobinuria using immunophenotyping of peripheral blood cells. Br J Haematol. 1991 Nov;79(3):487–492. doi: 10.1111/j.1365-2141.1991.tb08060.x. [DOI] [PubMed] [Google Scholar]
  59. Sears D. A., Anderson P. R., Foy A. L., Williams H. L., Crosby W. H. Urinary iron excretion and renal metabolism of hemoglobin in hemolytic diseases. Blood. 1966 Nov;28(5):708–725. [PubMed] [Google Scholar]
  60. Selvaraj P., Dustin M. L., Silber R., Low M. G., Springer T. A. Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor. J Exp Med. 1987 Oct 1;166(4):1011–1025. doi: 10.1084/jem.166.4.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Selvaraj P., Rosse W. F., Silber R., Springer T. A. The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria. Nature. 1988 Jun 9;333(6173):565–567. doi: 10.1038/333565a0. [DOI] [PubMed] [Google Scholar]
  62. Simmons D. L., Tan S., Tenen D. G., Nicholson-Weller A., Seed B. Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood. 1989 Jan;73(1):284–289. [PubMed] [Google Scholar]
  63. Stevens V. L., Raetz C. R. Defective glycosyl phosphatidylinositol biosynthesis in extracts of three Thy-1 negative lymphoma cell mutants. J Biol Chem. 1991 Jun 5;266(16):10039–10042. [PubMed] [Google Scholar]
  64. Stevens V. L. Regulation of glycosylphosphatidylinositol biosynthesis by GTP. Stimulation of N-acetylglucosamine-phosphatidylinositol deacetylation. J Biol Chem. 1993 May 5;268(13):9718–9724. [PubMed] [Google Scholar]
  65. Sugiyama E., DeGasperi R., Urakaze M., Chang H. M., Thomas L. J., Hyman R., Warren C. D., Yeh E. T. Identification of defects in glycosylphosphatidylinositol anchor biosynthesis in the Thy-1 expression mutants. J Biol Chem. 1991 Jul 5;266(19):12119–12122. [PubMed] [Google Scholar]
  66. Takahashi M., Takeda J., Hirose S., Hyman R., Inoue N., Miyata T., Ueda E., Kitani T., Medof M. E., Kinoshita T. Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria. J Exp Med. 1993 Feb 1;177(2):517–521. doi: 10.1084/jem.177.2.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Takeda J., Miyata T., Kawagoe K., Iida Y., Endo Y., Fujita T., Takahashi M., Kitani T., Kinoshita T. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell. 1993 May 21;73(4):703–711. doi: 10.1016/0092-8674(93)90250-t. [DOI] [PubMed] [Google Scholar]
  68. Thomas L. J., Urakaze M., DeGasperi R., Kamitani T., Sugiyama E., Chang H. M., Warren C. D., Yeh E. T. Differential expression of glycosylphosphatidylinositol-anchored proteins in a murine T cell hybridoma mutant producing limiting amounts of the glycolipid core. Implications for paroxysmal nocturnal hemoglobinuria. J Clin Invest. 1992 Apr;89(4):1172–1177. doi: 10.1172/JCI115700. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Udenfriend S., Micanovic R., Kodukula K. Structural requirements of a nascent protein for processing to a PI-G anchored form: studies in intact cells and cell-free systems. Cell Biol Int Rep. 1991 Sep;15(9):739–759. doi: 10.1016/0309-1651(91)90030-m. [DOI] [PubMed] [Google Scholar]
  70. Urakaze M., Kamitani T., DeGasperi R., Sugiyama E., Chang H. M., Warren C. D., Yeh E. T. Identification of a missing link in glycosylphosphatidylinositol anchor biosynthesis in mammalian cells. J Biol Chem. 1992 Apr 5;267(10):6459–6462. [PubMed] [Google Scholar]
  71. Vidugiriene J., Menon A. K. Early lipid intermediates in glycosyl-phosphatidylinositol anchor assembly are synthesized in the ER and located in the cytoplasmic leaflet of the ER membrane bilayer. J Cell Biol. 1993 Jun;121(5):987–996. doi: 10.1083/jcb.121.5.987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Wiedmer T., Hall S. E., Ortel T. L., Kane W. H., Rosse W. F., Sims P. J. Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. Blood. 1993 Aug 15;82(4):1192–1196. [PubMed] [Google Scholar]
  73. Yeh E. T., Reiser H., Bamezai A., Rock K. L. TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor. Cell. 1988 Mar 11;52(5):665–674. doi: 10.1016/0092-8674(88)90404-7. [DOI] [PubMed] [Google Scholar]
  74. Zalman L. S., Wood L. M., Frank M. M., Müller-Eberhard H. J. Deficiency of the homologous restriction factor in paroxysmal nocturnal hemoglobinuria. J Exp Med. 1987 Feb 1;165(2):572–577. doi: 10.1084/jem.165.2.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. van der Schoot C. E., Huizinga T. W., van 't Veer-Korthof E. T., Wijmans R., Pinkster J., von dem Borne A. E. Deficiency of glycosyl-phosphatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay. Blood. 1990 Nov 1;76(9):1853–1859. [PubMed] [Google Scholar]

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