Table 4.

Summary of effect of depression predicting likelihood of RTW post-MI at 6-8 and 12-13 months

Author	Finding	Ratio	Depression severity	Estimate of relative risk	CI (95%)	P value	Variables included in multivariate analysis** (bold indicates significance)
DEPRESSION SIGNIFICANTLY PREDICTED RTW
6-8 MONTHS
Fukuoka (2009)[28]	As a time-dependent covariate, increases in depression score predicted slower RTW at 6 months	Adjusted Hazard ratio*	Moderate depression Severe depression	0.47 0.37	0.31-0.72 0.21-0.66	< 0.001 0.001	Age, sex, nationality, education, income, marital status, smoking, hyperlipidemia, Duke activity index score (physical functioning), job strain, job satisfaction, job security, working hours per week, shift work, social support (from supervisor, co-workers)
Samkange-Zeeb (2006)[29]	Level of depression was significant predictor of RTW at 6 months	Adjusted Odds ratio	Borderline depression Clinical depression	0.62 0.28	0.35-1.12 0.14-0.58		Age, sex, profession, anxiety, expectations about work incapacity and desire to RTW
Soejima (1999)[31]	Depressed patients less likely to RTW at 8 months	Adjusted Odds ratio		0.15	0.02-0.87	< 0.031	Age, education, occupation, personality type health locus of control
12-13 MONTHS
McGee (2006)[35]	Baseline depression significantly predicted RTW at 12 months	Adjusted Odds ratio	HADS depression	0.2	0.06-0.6	0.007	Prior ACS, age and sex
Sykes (2000)[32]	Depression significant predictor of RTW at 12 months	Wald test		7.335 (df = 1)		0.0068	Decision latitude, work social interaction, age, medical prognosis (Coronary Prognostic Index)
Samkange-Zeeb (2006)[29]	Level of depression was significant predictor of RTW at 12 months	Adjusted Odds ratio	Borderline depression Clinical depression	0.35 0.24	0.18-0.68 0.11-0.49		Age, sex, profession, anxiety, expectations about work incapacity and desire to RTW
Soderman (2003) [5]	Clinical depression (BDI >16) predicted RTW at 12 months	Adjusted Odds ratio	Clinical depression Mild depression Clinical depression Mild depression	9.43 (fulltime) 2.89 (fulltime) 5.44 (reduced hours) OR not shown	3.15-28.21 1.08-7.70 1.60-18.53	<0.001 0.0300 <0.0068 0.7848	Gender, age, education, exercise capacity
Bhattacharyya (2007) [14]	Every increase in BDI index reduced likelihood of RTW at 12-13 months	Adjusted Odds ratio		0.90	0.82-0.99	0.032	Age, gender, risk of cardiac event, heart failure, antidepressant use, Arrhythmia during admission, recurrent cardiac events
DEPRESSION DID NOT SIGNIFICANTLY PREDICT RTW
6-12 MONTHS			Significant predictors
Brink [30]	Somatic health better predictor of RTW than mental health at 6 months	Adjusted Odds ratio	Physical health component score Footsteps per day	1.08 1.18	1.02-1.14 1.01-1.38	0.011 0.033	Physical health, age, footsteps per day
Ladwig (1994) [34]	Depression as a significant predictor of RTW at 6 months (OR: 0.39, Cl 0.18-0.88), was lost after adjustment for age, social class, rehabilitation, recurrent infarction, cardiac events, helplessness (OR: 0.54 CI 0.22-1.31)		-
Mayou (2000) [9]	No significant differences in RTW between distressed and nondistressed at 12 months		-
Engblom [27]	At 12 months, patients' expectations of work, duration of absence from work before CABS and physical capacity of patients after surgery are important determinants of RTW after CABS	Adjusted Odds ratio	Self assessed work capacity at six months (Good vs Poor) Functional Class (Canadian CVD class I vs II-III) Patient expectation about work (RTW vs retire) Absence from work before the CABS (3 months or less)	8.5 6.7 6.4 4.9	2.3-32.0 1.8-24.5 1.6-26.0 1.2-20.2	0.003 0.006 0.013 0.032	Type of rehabilitation, previous MI, expectations regarding work, physical strain of work, duration of the preoperative absence from work, basic education, professional education, socioeconomic status, preoperative BDI score, final work load at exercise test, functional class, patients' perception of working capacity at 6 months after the CABS.
Mittag [33]	Three variables predicted RTW at 12 months in 85% of all cases: (1) age, (2) patients' feelings about disability (3) physicians' views on the extent to which vocationally disabled	Adjusted Odds ratio	Age Self perceived disability Physician's view of disability	1.22 3.02 1.61	1.10-1.34 2.48-3.57 1.16-2.07	<0.01 <0.001 <0.05	Results of exercise testing, optimistic coping style, family income, negative incentives for RTW, physicians' subjective prognosis as to re-employment, patients' wish to return to work, age, self perceived vocational disability, physician's perception of patient disability.