Table 1.
Parameter estimates used in the baseline simulation.
parameter | symbol (units) | value |
---|---|---|
lattice spacing | dl (mm) | 0.01825a |
stress threshold | σcrit (kPa) | 35 (compressive)b |
initial smooth muscle cell concentration | cSMC,init (cells mm−3) | 3.16 × 104 c |
smooth muscle cell migration speed | vSMC (mm d−1) | 0.24d |
smooth muscle cell proliferation rate | pSMC (mitoses d−1) | 0.24a |
endothelial proliferation rate | pEC (mitoses d−1) | 2e |
initial matrix degrading factor | MDFinit (dimensionless) | 1e |
extracellular matrix degradation rate | cdeg (dimensionless) | 0.05e |
extracellular matrix production rate | (dimensionless) | 0.20e |
initial growth factor | G (dimensionless) | 3a |
eChosen to agree with time-course of restenosis studies/reviews (Edelman & Rogers 1998; Orford et al. 2000; Bennett & O'Sullivan 2001; Welt & Rogers 2002).