TABLE 3.
Results of mouse immunization study for HLA-A2-restricted cytotoxic-T-lymphocyte epitopes derived from HPV-58 E6 and E7 proteins
| Protein | Peptide sequence | Amino acid position | No. of IFN-γ spots/1 × 106 cellsa |
|---|---|---|---|
| HPV-58 E6 | TLHDLCQAL | 11-19 | 0 |
| ALETSVHEI | 18-26 | 64 | |
| FVFADLRIV | 45-53 | 0 | |
| AVCKVCLRL | 61-69 | 0 | |
| VCLRLLSKI | 65-73 | 37 | |
| RLLSKISEY | 68-76 | 0 | |
| TLEQTLKKC | 87-95 | 0 | |
| TLKKCLNEI | 91-99 | 0 | |
| ILIRCIICQ | 99-107 | 17 | |
| HPV-58 E7 | TLREYILDL | 7-15 | 0 |
| DLHPEPTDL | 14-22 | 0 | |
| CINSTATEV | 69-77 | 13 | |
| STATEVRTL | 72-80 | 0 | |
| EVRTLQQLL | 76-84 | 0 | |
| TLQQLLMGT | 79-87 | 0 | |
| QLLMGTCTI | 82-90 | 0 | |
| HPV-16 E7 | YMLDLQPETT | 11-20 | 25 |
a
The data represent the average numbers of spots from three mice.