TABLE 1.
HI profiles of MAb DPJY01 against H5 viruses of different lineages and other HA subtypes
| Clade or lineage group | Virusa | HI titer/50 μl |
|---|---|---|
| 0 | RG-A/Hong Kong/156/97 (H5N1)* | 12,800 |
| 1.0 | RG-A/Vietnam/1194/2004 (H5N1)* | 12,800 |
| 1.0 | RG-A/Vietnam/1203/2004(H5N1)* | 16,384 |
| 2.1 | RG-A/Indonesia/5/2005 (H5N1)* | 3,200 |
| 2.2 | A/egret/Egypt/1162-NAMRU3/2006 (H5N1) | 4,096 |
| 2.2 | RG-A/Turkey/1/2005 (H5N1)* | 3,200 |
| 2.3 | RG-A/Anhui/1/2005 (H5N1)* | 3,200 |
| North American lineage | A/Mallard Duck/Pensylvania/10218/84 (H5N2) | 4,096 |
| Eurasian lineage | RG-A/Mallard/NL/3/99 (H5N1) | 12,800 |
| A/WSN/1933 (H1N1) | <2 | |
| A/Mallard/New York/6750/78 (H2N2) | <2 | |
| A/Duck/Hongkong/3/75 (H3N2) | <2 | |
| A/Mallard/Alberta/206/96 (H6N8) | <2 | |
| A/Chicken/Delaware/VIVA/2004 (H7N2) | <2 | |
| A/Mallard/Alberta/194/92 (H8N4) | <2 | |
| A/Guinea fowl/Hong Kong/WF10/99 (H9N2) | <2 | |
| A/Pintail/Alberta/202/2000 (H10N7) | <2 | |
| A/Duck/MD/2T70/2004 (H11N9) | <2 | |
| A/Mallard/Alberta/238/96 (H12N5) | <2 | |
| A/Mallard/Alberta/146/2001 (H13N6) | <2 |
a
Viruses marked with an * are attenuated recombinant viruses generated by reverse genetics (RG). The HA genes of RG viruses were derived from the indicated virus. RG viruses contain the NA gene derived from A/egret/Egypt/1162-NAMRU3/2006 (H5N1) and a truncated NS1-73 gene derived from A/guinea fowl/Hong Kong/WF10/99 (H9N2). The other five genes of the RG viruses were derived from the WF10att backbone (25), with the exception of RG-A/Mallard/NL/3/99 (H5N1), for which the genes were derived from the WF10 wild-type backbone virus.