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. 2010 Jul 14;17(9):1330–1336. doi: 10.1128/CVI.00200-10

TABLE 1.

Biological results for 17 cystic fibrosis patients with proven or probable ABPAh

Patient no. Age (yr) Gendera Aspergillosis diagnosis Serum sample no.b Antibodies to A. fumigatus
 Total IgEf (kIU/liter) No. of Aspergillus colonies in sputum
rAspf4d (kAU/liter) rAspf6d (kAU/liter) IgGc index IE (precipitin no., enzymatic activitiese)
1 10 M ABPA 1 (m − 17) <0.10 <0.10 0.37 0 15.5 ND
2 (m − 2) <0.10 <0.10 0.58 3, cat+ 553 ND
3 (m + 7) 0.11 0.10 1.58 7, cat+, chym+ 3,090 0
4 (m + 20) 0.60 0.42 1.53 2, cat+ 422 0
5 (m + 32) 6.52 2.75 2.92 3, cat+ ND 0
2 6 F ABPA 6 (m − 17) NDg ND 0.4 0 ND ND
7 (m0) <0.10 <0.10 1.83 4, cat+ 289 3
8 (m + 13) 0.13 0.13 2.12 2, cat+ 292 0
9 (m + 30) 3.25 1.66 3.37 2, cat+ ND 0
10 (m + 40) 7.28 1.7 0.7 2, cat+ 2,140 1
3 14 M ABPA 11 (m0) <0.10 <0.10 3.34 4, cat+ 945 0
12 (m + 18) 0.98 0.20 1.48 3, cat+ 362 0
13 (m + 30) 3.09 1.00 2.6 2 889 0
14 (m + 38) 2.81 0.34 1.16 1 711 0
15 (m + 47) 0.52 2.27 5.34 3, cat+ 839 0
4 13 F ABPA 16 (m0) 1.62 0.34 1.38 3, cat+ 184 0
17 (m + 6) 0.47 0.11 0.64 2, cat+ 70 0
18 (m + 14) 0.27 0.1 0.35 0 33 0
19 (m + 21) 0.11 <0.10 0.58 0 <18 0
20 (m + 32) 0.77 0.14 2.15 3, cat+ 138 0
5 5 M ABPA 21 (m − 2) <0.10 0.10 0.51 1 805 ND
22 (m0) 3.49 0.28 1.77 5, cat+ 3,190 3
23 (m + 30) 3.74 0.28 0.63 0 1,650 0
24 (m + 48) 8.15 0.55 3.9 3 4,250 ND
25 (m + 54) 7.21 1.74 0.88 2 3,580 0
6 8 M ABPA 26 (m − 12) 1.17 <0.10 1.61 2 403 0
27 (m − 6) 2.79 <0.10 2.29 2 417 ND
28 (m0) 4.37 <0.10 1.87 2, cat+ 777 1
29 (m + 6) 5.45 <0.10 2.82 3, cat+ 726 0
30 (m + 12) 4.24 <0.10 1.77 2, cat+ 918 0
7 10 F ABPA 31 (m − 4) <0.10 <0.10 0.36 0 QI 0
32 (m + 2) 0.64 <0.10 3.43 4, cat+ 227 3
33 (m + 11) 0.59 <0.10 4.61 7, cat+ 212 0
34 (m + 12) 0.35 <0.10 3.88 5, cat+ 142 ND
35 (m + 23) <0.10 <0.10 0.66 0 24 0
8 18 F ABPA 36 (m − 15) 0.80 <0.10 1.59 1 798 0
37 (m0) 2.56 <0.10 1.92 3, cat+ 2,380 0
38 (m + 9) 0.86 <0.10 1.06 1, cat+ 924 0
39 (m + 15) 1.07 <0.10 1.13 2 866 0
40 (m + 26) 0.37 <0.10 0.88 0 338 0
41 (m + 34) 0.58 <0.10 1.12 2 918 0
9 16 F ABPA 42 (m0) <0.10 <0.10 0.82 6, cat+ 198 ND
43 (m + 7) <0.10 <0.10 0.92 4 137 3
44 (m + 15) 0.20 <0.10 1.04 7, cat+ 169 3
45 (m + 31) 0.63 <0.10 1.70 4, cat+, chym+ 351 5
46 (m + 38) 1.64 <0.10 1.95 4, cat+ 622 15
10 16 F ABPA 47 (m − 25) <0.10 <0.10 0.03 0 426 ND
48 (m + 20) 2.03 <0.10 1.80 4, cat+ 1,080 ND
49 (m + 23) 1.03 <0.10 1.81 3, cat+ 716 ND
50 (m + 34) 0.51 <0.10 1.22 2, cat+ 612 ND
51 (m + 60) 0.16 <0.10 3.03 2, cat+ 531 ND
11 18 M ABPA 52 (m0) <0.10 <0.10 3.06 7, cat+, chym+ 268 ND
53 (m + 12) 0.10 0.27 2.78 3 407 1
54 (m + 19) <0.10 0.14 1.56 5, cat+ 272 5
55 (m + 24) <0.10 0.18 3.12 5, cat+ 304 ND
56 (m + 27) 0.11 0.19 2.57 5, cat+ 449 6
12 8 M ABPA 57 (m0) <0.10 <0.10 1.21 6, cat+ 18 6
13 21 F ABPA 58 (m + 84) 1.58 2.04 0.48 0 618 0
14 18 F Probable ABPA 59 (m − 28) <0.10 <0.10 1.13 2 ND 1
60 (m − 16) <0.10 <0.10 1.30 6, cat+ ND 5
61 (m − 8) <0.10 <0.10 2.04 4, cat+ 11 1
62 (m + 13) <0.10 <0.10 2.35 7, cat+ 10 9
63 (m + 26) <0.10 <0.10 2.70 6, cat+ ND 15
15 19 M Probable ABPA 64 (m − 53) <0.10 <0.10 0 0 24 3
65 (m − 12) <0.10 <0.10 0.48 0 792 2
66 (m0) <0.10 <0.10 1.14 3 1,090 ND
67 (m + 13) 0.76 <0.10 2.35 1 1,540 ND
16 9 F Probable ABPA 68 (m − 5) <0.10 <0.10 0.51 0 76 0
69 (m0) <0.10 <0.10 0.75 0 526 1
70 (m + 1) <0.10 0.24 0.41 1, cat+ 224 ND
71 (m + 8) <0.10 0.10 0.27 0 137 1
72 (m + 23) <0.10 0.63 0.32 2 180 0
17 13 M Probable ABPA 73 <0.10 <0.10 1.16 3 17 20
a

M, male; F, female.

b

The month of serum sampling (m +/−) in respect to the month of aspergillosis diagnosis (m0) for each patient is given in parentheses.

c

Anti-Aspergillus ELISA IgG. An index value of >0.75 was considered positive.

d

Specific IgE against two A. fumigatus recombinants measured by the Pharmacia UniCAP method. A result of >0.1 kAU/liter was considered positive.

e

IE for precipitin detection. More than 2 precipitin lines was considered positive. Positive enzymatic activities (catalase and chymotrypsin) are indicated (+).

f

Total IgE measured by the Pharmacia UniCAP method. A result of >500 kIU/liter was considered positive.

g

ND, not determined.

h

Positive results are shown in boldface type.