Table 2.
Effect of NTS pretreatment on ANG-(1–12)-mediated mean AP and HR responses
| Group | Mean AP, mmHg | HR, Beats/min |
|---|---|---|
| Candesartan alone | ||
| Baseline | 89 ± 7 | 319 ± 28 |
| Peak | 73 ± 10* | 275 ± 33 |
| 10 min | 81 ± 6 | 277 ± 33 |
| Candesartan + ANG-(1–12) | ||
| Baseline | 89 ± 7 | 302 ± 26 |
| Peak | 87 ± 8 | 305 ± 21 |
| 10 min | 91 ± 7 | 307 ± 23 |
| BPP9 alone | ||
| Baseline | 78 ± 3 | 284 ± 11 |
| Peak | 74 ± 7 | 267 ± 7* |
| 10 min | 73 ± 5 | 269 ± 8 |
| 60 min | 75 ± 7 | 275 ± 10 |
| BPP9α + ANG-(1–12) | ||
| Baseline | 74 ± 6 | 287 ± 15 |
| Peak | 77 ± 7 | 280 ± 19 |
| 10 min | 81 ± 3 | 282 ± 18 |
Values are means ± SE and represent mean AP and HR at baseline (immediately before injections), peak changes in response to NTS injections of inhibitors alone or inhibitors followed by subsequent administration of ANG-(1–12), and values after injection (immediately before reflex testing); n = 4 animals for each group.
*
P < 0.05 vs. respective baseline.