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. 2010 Jul 2;299(3):H799–H810. doi: 10.1152/ajpheart.00170.2010

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Fig. 6. — Histological and echocardiographic detection of enlarged hearts and diminished cardiac contractility in CHT^+/− mice. A: ratio of heart weight (HW; in g) to body weight (BW; in g) × 1,000. Values are means ± SE; n = 7 CHT^+/+ mice and 9 CHT^+/− mice. Significance was determined using a one-tailed, unpaired Student's t-test (*P < 0.05 compared with the CHT^+/+ group). B: fractional shortening (in %) calculated by images at both maximal systole and diastole. C: measure of left ventricular mass (in g) in young (2–3 mo old) and aged (10–12 mo old) CHT^+/+ and CHT^+/− mice. Values are means ± SE; n = 8 mice/group (young CHT^+/+, young CHT^+/−, aged CHT^+/+, and CHT^+/− groups) Significance was determined using a one-tailed, unpaired Student's t-test (genotype × same age group) (*P < 0.04, **P < 0.02, and +P < 0.05, young vs. aged CHT^+/− mice).