Table 1.

Baseline cardiovascular characteristics and neurochemistry profiles of CHT^+/+ and CHT^+/− mice

Parameter	No. of Mice/Group	CHT+/+ Mice	CHT+/− Mice	P Value
HR (day, resting), beats/min	8	538.8 ± 8.16	567.0 ± 8.12*	0.0172
HR (night, activity), beats/min	8	682.6 ± 6.50	696.6 ± 8.50	0.1951
Mean BP (day), mmHg	7	98.20 ± 1.18	104.9 ± 2.06*	0.035
Systolic BP (resting), mmHg	7	111.0 ± 1.48	118.4 ± 1.90*	0.035
Diastolic BP (resting), mmHg	7	84.90 ± 1.63	91.54 ± 3.23	0.181
Systolic BP (activity), mmHg	7	117.5 ± 3.79	124.1 ± 3.93	0.291
Diastolic BP (activity), mmHg	7	108.4 ± 0.051	103.8 ± 0.77	0.180
ΔHR with metoprolol (2 mg/kg ip), beats/min	8	−166.0 ± 36.57	−66.83 ± 22.23*	0.022
ACh, nmol/g tissue		6.2 ± 0.8	3.7 ± 0.7	0.05
Choline, nmol/g tissue		305.2 ± 41.6	225.3 ± 23.0	0.05
Urinary norepinephrine, pg/μl		125 ± 10.3	195.8 ± 34.5	0.05
Urinary epinephrine, pg/μl		3.9 ± 0.3	6.8 ± 1.3	0.05
Plasma norepinephrine, pmol/ml		17.40 ± 5.86	31.93 ± 8.96	0.123
Plasma 3,4-dihydroxyphenylethylene glycol, pmol/ml		13.68 ± 1.94	19.23 ± 2.14	0.05

Values are reported as means ± SE. CHT, choline transporter; CHT^+/+ mice, wild-type mice; CHT^+/− mice, CHT heterozygous mice; HR, heart rate; BP, blood pressuer. Significance was determined using a one-tailed, unpaired Student's t-test.

^*P < 0.05, CHT^+/− compared with CHT^+/+ mice.