Skip to main content
. 2010 Jun 11;299(3):H827–H836. doi: 10.1152/ajpheart.00129.2010

Fig. 2.

Fig. 2.

A: the effect of different concentrations of sildenafil (0.01–10 μM) at reperfusion on infarct size. Mouse hearts were subjected to 30 min global ischemia and 120 min of reperfusion. Bars represent means ± SE; n = 4–9 animals. *P < 0.001 vs. control (1-way ANOVA). B: the time dependence of protection by 0.1 μM sildenafil at reperfusion, assessing 10, 30, 60, or 120 min. Bars represent means ± SE; n = 5–11 animals. ***P < 0.001 vs. control; **P < 0.01 vs. control; *P < 0.05 vs. control (1-way ANOVA). Sildenafil administration beyond 10 min did not further attenuate infarction. C: the effect of 0.1 μM sildenafil administered at reperfusion on myocardial infarction in wild-type (WT) or natriuretic peptide receptor-A (NPR-A) null tissue following ischemia and reperfusion. Sildenafil (0.1 μM) was given at the onset of reperfusion for the first 10 min and protected both WT and NPR-A null hearts. Bars represent means ± SE; n = 5–13 animals. *P < 0.05 vs. control (1-way ANOVA). Infarction has been measured as infarction volume as a percentage of total myocardial volume. KO, knockout.