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. 2010 Jul 2;299(3):H634–H642. doi: 10.1152/ajpheart.00347.2010

Fig. 6.

Fig. 6.

Response to a bolus caffeine injection after a prolonged low-dose Iso infusion (n = 4). A: effect of a bolus caffeine (20 mmol/l) injection in the normal RA. Note the superior shift of the leading pacemaker site with robust LDCAE (*) with a HR of 127 beats/min. B: effect of a bolus caffeine injection after a prolonged low-dose Iso infusion. Note the robust LDCAE (*) from the superior SAN. The leading pacemaker site was the inferior RA with a HR of 150 beats/min. C: comparison of LDCAE slopes during caffeine alone and Iso plus caffeine infusion. D: comparison of HRs during caffeine alone and Iso plus caffeine infusion.