Induction of both diabetes mellitus (DM) and hypercholesterolemia (HC) results in advanced atherosclerosis. Representative histological samples: control (A), DM only (B), HC only (C), and DM/HC (D). While HC only produces atherosclerosis (AS), only the DM/HC group developed complex lesions as evidenced by a large necrotic core (NC), calcifications (asterisks), and a thin fibrous cap (arrowhead). FC, fibrous cap. Movat pentachrome staining.