Fig. 1.

Cardioprotection by preconditioning following classical second window or chronic ischemia. Description of the experimental protocols (A) used for microarray analysis or for measurement of infarct size in the different groups. Reduction of infarct size (B) by the different protocols of preconditioning and the effect thereupon of nitric oxide (NO) blockade with N-nitro-l-arginine (l-NNA) (n = 4/group) compared with vehicle (n = 5/group), administered intravenously before lethal coronary occlusion. CAR, coronary artery reperfusion; RCO, repetitive coronary occlusion; RCS, repetitive coronary stenosis; SWOP, second window of preconditioning. *P < 0.05 vs. control. #P < 0.05 vs. SWOP + l-NNA.