FIG. 3.

Regulatory network controlling spa and hla expression. Regulatory loci directly or indirectly influencing spa transcription, either positively (arrows) or negatively (blocked arrows), are indicated. Regulators analyzed here are represented by filled ovals. SarT and SarU, shown as light shaded ovals, form part of the S. aureus core variable region RD5, which is absent from strain CHE482. Other regulatory connections reported in the literature are shown by broken lines. These regulatory connections are documented in references 3, 7, 12, 13, 15, 18-20, 26, 27, 32, 34-36, 45-50, 52, 55, 57, 64, 66, 67, 73, and 74. Reference numbers are given in parentheses on the figure.