TABLE 3.

ORFs differentially regulated by xdrA deletion in S. aureus CHE482

Gene IDa	Name	Gene product	Fold change in expressione
Upregulated genes
SAR0153	capC	Capsular polysaccharide synthesis enzyme	4.2
SAR0154	capD	Capsular polysaccharide synthesis enzyme	3.4
SAR0179		Putative transporter protein	3.8
SAR0227*	fadX	Putative acetyl-CoA transferase	9
SAR0228		Putative glutamine amidotransferase class I	3
SAR0420		Putative membrane protein	3.5
SAR0995*		Putative regulatory protein	13.4
SAR1740		DNA repair protein (partial)	13.5
SAR1741*		Type III leader peptidase family protein	14.7
SAR1812	acuA	Acetoin utilization protein	5.5
SAR1813		Histone deacetylase family protein	4.1
SAR2396		DeoR family regulatory protein	4.1
SAR2413*		Putative short chain dehydrogenase	8.7
SAR2587		Hypothetical protein	4.3
SAR2610		Putative l-serine dehydratase, alpha chain	4.7
SAR2611		Putative l-serine dehydratase, beta chain	4.9
SAR2612		Putative membrane protein	5.3
SAR2643	crtM	Squalene desaturase (pseudogene)	4
SAR2645		Putative glycosyl transferase	5
SAR2646		Putative phytoene dehydrogenase related protein	4.3
SAR2647		Putative membrane protein	3.6
SAR2762		Hypothetical protein	3.7
MW0377b		Conserved hypothetical protein	12
MW0378b		Conserved hypothetical protein	14.3
Downregulated genes
SAR0114*	spa	Immunoglobulin G binding protein A precursor	32.5
SAR0178		Putative d-isomer specific 2-hydroxyacid dehydrogenase	3.2
SAR0435		Exotoxin	7.8
SAR0696		Putative exported protein	3.1
SAR0787	sstA	FecCD transport family protein	3.1
SAR0788	sstB	FecCD transport family protein	3.0
SAR0789	sstC	ABC transporter ATP-binding protein	3.2
SAR0790	sstD	Lipoprotein	3.3
SAR0806		Putative S30EA family ribosomal protein	5.3
SAR0866		Hypothetical protein	3.2
SAR0996*		Conserved hypothetical protein	7.7
SAR1041		Conserved hypothetical protein	3.4
SAR1042	purQ	Putative phosphoribosylformylglycinamidine synthase I	4.3
SAR1043	purL	Putative phosphoribosylformylglycinamidine synthase II	3.2
SAR1450	tdcB	Putative threonine dehydratase	3.5
SAR1451	ald2	Alanine dehydrogenase 2	4.8
SAR1849		Proline dehydrogenase	3.2
SAR1938 (SA1665; xdrA)		Putative DNA-binding protein	71.4
SAR2244*	mtlA	PTS system, mannitol-specific IIBC component	15.2
SAR2245		Putative transcriptional antiterminator	5.5
SAR2247	mtlD	Putative mannitol-1-phosphate 5-dehydrogenase	3.5
SAR2589*		Putative transporter protein	6.4
SAR2593		Putative transcriptional regulator	3.5
SAR2605	ddh	d-Specific d-2-hydroxyacid dehydrogenase	3.3
SACOL0478c		Exotoxin 3	8.6
SA0393d	set15	Exotoxin 15	8.1

^aGene identifications (IDs) refer to S. aureus strain MRSA252 unless otherwise indicated. Genes selected for Northern blot analysis are marked with asterisks.

^bGene probes on microarrays were obtained from S. aureus MW2.

^cGene probes on microarrays were obtained from S. aureus COL.

^dGene probes on microarrays were obtained from S. aureus N315.

^eP < 0.05.