FIG. 4.

Change of bioavailability of voriconazole over postoperative time (POT) in patients with and without cystic fibrosis (CF). Individual parameter estimates of bioavailability obtained from model 2 were plotted against postoperative time. Bioavailability significantly, rapidly increased with POT in most of the patients, and eventually reached the maximal level within 1 week after transplant. Bioavailability was significantly lower in CF patients (dashed line) than non-CF patients (solid line). Solid gray line, population estimates from model 2.