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PDB exhibits anti-HIV-1 activity even after exposure of target cells to virus. P4-R5 MAGI cells were infected with HIV-1IIIB at a titer of 104 TCID50/ml for 30 min, followed by washout of the virus inoculum, and then PDB (5 μM) was added for 48 h. Cells were harvested, and the total enzymatic activity of β-Gal in lysates was measured. Means ± SE of results from 3 independent experiments are shown.
