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. 2010 Jul 12;54(10):4513–4515. doi: 10.1128/AAC.00674-10

FIG. 1.

FIG. 1.

Survival rates and lung fungal burdens of rats infected with A. fumigatus and treated with PTX3 (n = 16). (A) Survival curves of rats treated daily with PTX3 3 days before the day of infection and then for an additional 3 days (schedule ii). (B) Survival curves of rats treated with PTX3 the same day of infection and then daily for an additional 3 days (schedule iii). Unbroken line, 1.5 mg/kg PTX3; dashed line, 0.15 mg/kg PTX3; dotted line, saline. (C) Fungal burden of rats treated with PTX3 according to schedule ii. (D) Fungal burden of rats treated with PTX3 according to schedule iii. The fungal burden was measured by evaluation of galactomannan content in the lung and was expressed as a positivity index (GMI). Dots represent the GMI from a single animal. Means are represented by bars. *, P < 0.05; **, P < 0.005; and ***, P < 0.001 (compared to the vehicle). The experiments were repeated at least twice.