TABLE 2.
Treatment of T. b. brucei EATRO110 acute mouse infections with oxaborolesa
| Compound | Dose (mg/kg) | Route | No. of cured mice/total no. of mice | Avg. survival (no. of days) | % cured |
|---|---|---|---|---|---|
| AN3520 | 5 | p.o. | 3/3 | >30 | 100 |
| 10 | p.o. | 2/3 | 11b | 67 | |
| SCYX-6759 | 1.25 | p.o. | 3/5 | 10.5b | 60 |
| 2.5 | p.o. | 5/5 | >30 | 100 | |
| 5 | p.o. | 3/3 | >30 | 100 | |
| 10 | p.o. | 3/3 | >30 | 100 | |
| Diminazene aceturate | 2 | i.p. | 3/3 | >30 | 100 |
| Untreated | 0/5 | 4 | 0 |
a
Mice were infected with 250,000 T. b. brucei EATRO 110 parasites, and the infection was allowed to progress for 24 h prior to initiation of treatment. Parasitemia was examined weekly, and cures were determined as described in Materials and Methods. Infected animals were dosed twice daily for 4 consecutive days. Diminazene aceturate was administered as a single i.p. dose to serve as a positive control. Cured animals are defined as those that remained aparasitemic for >30 days after the start of the dosing period.
b
Average survival of mice showing relapse.