TABLE 3.

Treatment of T. b. brucei TREU667 CNS infections with oxaboroles^a

Compound tested	Dose (mg/kg)	Dosing route	Duration (no. of days)	Avg. no. of days until relapse	No. of cured mice/total no. of mice	% cured
AN3520	50	i.p.	14	52.5	7/9	78
	50	i.p.	7	57	12/17	71
	25	i.p.	14	51.6	2/10	20
	25	i.p.	7	39.1	1/17	6
	12.5	i.p.	7	35	0/8	0
SCYX-6759	50	i.p.	14		10/10	100
	50	p.o.	7	56	5/6	83
	25	p.o.	7	38.8	2/10	20
	12.5	p.o.	7	35.7	1/10	10
	6	p.o.	7	36.6	1/10	10
Diminazene aceturate	10	i.p.	1 (D4)		10/10	100
	10	i.p.	1 (D21)	48.3	0/10	0

^aMice were infected with 10,000 T. b. brucei TREU667 parasites, and the infection was allowed to progress for 21 days prior to initiation of treatment. Parasitemia was examined weekly, and cures were determined as described in Materials and Methods. Compounds were administered twice daily for 7 or 14 consecutive days. Diminazene aceturate was administered as a single i.p. dose on day 4 (D4) or day 21 (D21) to serve as positive and negative controls, respectively. Cured animals are defined as those that remained aparasitemic for >180 days after the start of the dosing period.