TABLE 4.
MDCKII-hMDR1 permeability
| Compound | Papp A→B (nm/s) | Papp A→B+GF918 (nm/s) | Mass balance (%) |
Absorption quotient | P-gp classification | |
|---|---|---|---|---|---|---|
| A→B | A→B+GF918 | |||||
| AN3520 | 424 | 434 | 92 | 90 | 0.02 | Nonsubstrate |
| SCYX-6759 | 379 | 386 | 89 | 95 | 0.02 | Nonsubstrate |
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