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Potential for AN3520 and SCYX-6759 to inhibit cytochrome P450 enzyme activities
| CYP isoform | IC50 (μM)a |
|
|---|---|---|
| AN3520 | SCYX-6759 | |
| 3A4 | >100 | >100 |
| 2D6 | 38.7 | 30.3 |
| 2C9 | 29.6 | 30.6 |
| 2C19 | 69.7 | 47.4 |
| 1A2 | >100 | >100 |
The potential of drug-drug interactions was classified as high (IC50 < 1 μM), moderate (1 μM < IC50 < 10 μM), or low (IC50 > 10 μM), according to the observed level of enzyme inhibition. The values are expressed as the means from triplicate determinations.
