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Pharmacokinetic parameters for SCYX-6759 in male Sprague-Dawley rats in brain and CSF following oral administration
| Matrix | Dose (mg/kg) | AUC0→last (μg·h/ml) | tlast (h) | AUC0→∞ (μg·h/ml) | t1/2 (h) | Tmax (h) | Cmax (μg/m) |
|---|---|---|---|---|---|---|---|
| Brain | 13.4 | 4.1 | 12 | 4.4 | 6 | 1 | 0.99 |
| 23.5 | 11.9 | 18 | 11.9 | 2.6 | 2 | 2.32 | |
| 50.2 | 26.8 | 12 | 27.2 | 2.9 | 2 | 5.5 | |
| CSF | 13.4 | 2.02 | 12 | 2.02 | 4.6 | 1 | 0.364 |
| 23.5 | 3.61 | 12 | 3.65 | 3.1 | 4 | 1.13 | |
| 50.2 | 6.33 | 12 | 6.33 | 2.5 | 6 | 1.22 |
