TABLE 1.
QN responses of P. falciparum strains and polymorphisms in the pfnhe1, pfmdr1, and pfcrt genes
| Parasite isolate | IC50 (nM) (mean ± SD) |
pfnhe1 ms4760a |
pfmdr1 codonb |
pfcrt codon(s)b |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype | Rep1 | Rep2 | 86 | 184 | 1034 | 1042 | 1246 | 72-76 | 220 | ||
| F07-7 | 456 ± 33 | 1 | 2 | 2 | N | Y | S | N | D | CVIET | S |
| F07-10 | 306 ± 16 | 1 | 2 | 2 | N | Y | S | N | D | CVIET | S |
| F07-23 | 447 ± 71 | 1 | 2 | 2 | N | Y | S | N | D | CVIET | S |
| F07-50 | 204 ± 13 | 1 | 2 | 2 | N | F | S | N | D | CVIET | S |
| F07-59 | 197 ± 15 | 1 | 2 | 2 | N | F | S | N | D | CVIET | S |
| F08B53 | 468 ± 68 | 1 | 2 | 2 | N | Y | S | N | D | CVIET | S |
| F09N1 | 191 ± 46 | 1 | 2 | 2 | N | Y | S | D | D | CVIET | S |
| F09N18 | 284 ± 45 | 1 | 2 | 2 | N | Y | S | N | D | CVIET | S |
| F07-13 | 365 ± 61 | 3 | 1 | 2 | N | Y | S | N | D | CVIET | S |
| F09A54 | 243 ± 32 | 3 | 1 | 2 | N | F | S | N | D | CVIET | S |
| F09A55 | 149 ± 26 | 3 | 1 | 2 | N | F | S | N | D | CVIET | S |
| F09A9 | 562 ± 128 | 5 | 4 | 1 | N | Y | S | N | D | CVIET | S |
| F09N72 | 500 ± 47 | 5 | 4 | 1 | N | Y | S | N | D | CVIET | S |
| F07-3 | 875 ± 44 | 6 | 2 | 1 | N | Y | S | N | D | CVIET | S |
| F07-9 | 321 ± 101 | 6 | 2 | 1 | N | F | S | N | D | CVIET | S |
| F07-11 | 629 ± 81 | 6 | 2 | 1 | N | Y | S | N | D | CVIET | S |
| F07-46 | 894 ± 56 | 6 | 2 | 1 | N | Y | S | N | D | CVIET | S |
| F07-56 | 427 ± 52 | 6 | 2 | 1 | N | Y | S | N | D | CVIET | S |
| F08B32 | 302 ± 45 | 6 | 2 | 1 | N | F | S | N | D | CVIET | S |
| F09N35 | 905 ± 28 | 6 | 2 | 1 | N | F | S | N | D | CVIET | S |
| F09N58 | 448 ± 109 | 6 | 2 | 1 | N | F | S | N | D | CVIET | S |
| F09N66 | 711 ± 78 | 6 | 2 | 1 | N | F | S | N | D | CVIET | S |
| F09N68 | 288 ± 82 | 6 | 2 | 1 | N | F | S | N | D | CVIET | S |
| F07-6 | 543 ± 39 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F07-8 | 874 ± 12 | 7 | 3 | 1 | N | F | S | D | D | CVIET | S |
| F07-25 | 502 ± 45 | 7 | 3 | 1 | N | F | S | N | D | CVIET | S |
| F07-27 | 650 ± 44 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F07-28 | 473 ± 25 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F07-29 | 282 ± 5 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F07-31 | 433 ± 32 | 7 | 3 | 1 | N | F | S | N | D | CVIET | S |
| F07-35 | 821 ± 224 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F07-40 | 298 ± 53 | 7 | 3 | 1 | Y | Y | S | N | D | CVIET | A |
| F07-42 | 388 ± 95 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F07-58 | 680 ± 91 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F08B2 | 1,016 ± 196 | 7 | 3 | 1 | N | F | S | N | D | CVIET | S |
| F08B9 | 218 ± 31 | 7 | 3 | 1 | N | F | S | N | D | CVIET | S |
| F08B27 | 870 ± 111 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F08B41 | 886 ± 61 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F08B61 | 1,128 ± 106 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F08B63 | 579 ± 20 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F08B72 | 583 ± 78 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09A10 | 716 ± 8 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09A41 | 1,295 ± 99 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09A61 | 373 ± 27 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09N6 | 710 ± 45 | 7 | 3 | 1 | N | Y | S | D | D | CVIET | S |
| F09N22 | 535 ± 37 | 7 | 3 | 1 | N | F | S | N | D | CVIET | S |
| F09N29 | 853 ± 45 | 7 | 3 | 1 | N | Y | S | D | D | CVIET | S |
| F09N33 | 490 ± 28 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09N40 | 2,123 ± 93 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09N44 | 514 ± 26 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09N64 | 475 ± 66 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09N78 | 513 ± 18 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| Feng | 371 ± 44 | 7 | 3 | 1 | N | Y | S | N | D | CVIET | |
| PF18 | 300 ± 48 | 7 | 3 | 1 | N | Y | S | N | D | SVMNT | S |
| F07-34 | 574 ± 33 | 9 | 3 | 2 | N | Y | S | N | D | CVIET | S |
| F08B7 | 1,099 ± 283 | 9 | 3 | 2 | N | Y | S | N | D | CVIET | S |
| F08B60 | 767 ± 32 | 14 | 3 | 1 | N | Y | S | N | D | CVIET | S |
| F09A21 | 258 ± 26 | 18 | 2 | 2 | N | Y | S | N | D | CVIET | S |
| F07-47 | 324 ± 21 | 20 | 4 | 1 | N | F | S | N | D | CVIET | S |
| F08B40 | 260 | 21 | 1 | 1 | N | F | S | N | D | CVIET | S |
| SM | 188 ± 33 | 6 | 2 | 1 | Y | Y | S | N | D | CVIET | S |
| FCC1/HN | 179 ± 68 | 6 | 2 | 1 | N | Y | S | N | D | CVIET | S |
| W2 | 720 ± 221 | 1 | 2 | 2 | Y | Y | S | N | D | CVIET | S |
| 3D7 | 108 ± 48 | 2 | 1 | 2 | N | Y | S | N | D | CVMNK | A |
| 7G8 | 619 ± 73 | 1 | 2 | 2 | N | F | C | D | Y | SVMNT | S |
| Dd2 | 602 ± 87 | 1 | 2 | 2 | Y | Y | S | N | D | CVIET | S |
| K1 | 407 ± 75 | 5 | 4 | 1 | Y | Y | S | N | D | CVIET | S |
| HB3 | 319 ± 55 | 5 | 4 | 1 | N | F | S | D | D | CVMNK | A |
a
The Rep 1 column indicates the number of DNNND repeats; the Rep 2 column shows the number of NHNDNHNNDDD repeats.
b
Letters in bold indicate point mutations.