TABLE 2.

Summary of the association of in vitro QN response (IC₅₀) with polymorphisms in the pfnhe1, pfmdr1, and pfcrt genes from P. falciparum isolates

Genotype and basis of analysis	P valuea		Significance
	All samplesb	60 field isolates
pfnhe1
ms4760 haplotype	0.010	0.003	S
His/Asp ratio	0.003	0.001	S
No. of DNNND repeats	0.001	0.003	S
No. of DDNHNDNHNND repeats	0.012	0.001	S
pfmdr1
Codon 86	0.573	0.400	NS
Codon 184	0.067	0.022	NS
Codon 1034	0.647		NS
Codon 1042	0.519	0.501	NS
Codon 1246	0.647		NS
pfcrt
Codons 72 to 76	0.198	0.433	NS
Codon 220	0.407	0.040	NS

^aP values were determined with the Kruskal-Wallis test. The variables analyzed were the QN IC₅₀s. S, significant; NS, not significant (cutoff of P = 0.0045 [Bonferroni correction]).

^bAll samples included 60 new isolates, 8 laboratory standard strains, and 2 strains established earlier in China.