TABLE 2.
The effect of antifungal treatment on colony counts in lung, spleen, and brain on day 11 after challenge
| Isolate | Drug (dose [mg/kg/day]) | Mean log10 CFU/g (95% CI)c |
||
|---|---|---|---|---|
| Lung | Spleen | Brain | ||
| FMR 8396 | None | — | — | — |
| PSC (10) | 3.55 (2.26-4.83) | 1.60 (0.43-2.76)a | 4.52 (3.89-5.15)b | |
| PSC (20) | 4.22 (3.75-4.90) | 0.87 (−0.10 to 1.84)a | 4.38 (3.99-4.77)b | |
| PSC (40) | 1.67 (0.08-3.25) | NDa | 4.35 (3.70-5.34)b | |
| VRC (10) | 4.62 (3.90-5.34) | 4.38 (3.94-4.81)b | 4.64 (4.13-5.14)b | |
| VRC (40) | 4.52 (3.99-5.05) | 4.15 (3.86-4.45)b | 4.05 (3.64-4.46)b | |
| VRC (60) | 3.89 (3.05-4.73) | 4.20 (2.37-4.49)b | 4.13 (3.74-4.52)b | |
| AMB (1.5) | NDa | NDb | 1.04 (0.56-1.52)a | |
| FMR 8394 | None | — | — | — |
| PSC (10) | NDa | NDa | 6.61 (6.47-6.75)b | |
| PSC (20) | NDa | NDa | 6.12 (5.33-6.92)b | |
| PSC (40) | ND | NDa | 3.55 (3.06-4.03)b | |
| AMB (1.5) | ND | ND | 3.05 (2.50-3.61)a | |
a
P < 0.05 versus fungal load on day 5 of therapy (significantly lower).
b
P < 0.05 versus fungal load on day 5 of therapy (significantly higher).
c
CI, confidence interval; —, control mice did not survive to day 11; ND, not detected.