TABLE 1.
Pharmacokinetic parameters of mother-infant pairs following a single intrapartum dose of maraviroca
| Animal | Dose (mg/kg) | Cmax (ng/ml) | Tmax (h) | Clast (ng/ml) | Tlast (h) | T1/2 (h) | AUC0-12 (ng·h/ml) | AUCT (ng·h/ml) | Cmax ratio (I/M) | AUCT ratio (I/M) |
|---|---|---|---|---|---|---|---|---|---|---|
| Mother A | 60 | 2,830 | 2 | 2.9 | 48 | 7.2 | 15,696 | 18,275 | ||
| Infant A | 99 | 2 | 1.0 | 24 | NC | 197 | 235 | 0.03 | 0.013 | |
| Mother B | 60 | 927 | 2 | 14.8 | 50 | 18.3 | 3,479 | 4,718 | ||
| Infant B | 17 | 2 | 2.0 | 8 | NC | NC | 26 | 0.02 | 0.006 | |
| Mother C | 100 | 1,022 | 1.3 | 12.7 | 48 | 21.1 | 2,970 | 4,301 | ||
| Infant C | 28 | 2 | 2.8 | 8 | NC | NC | 66 | 0.03 | 0.015 | |
| Mother D | 100 | 86 | 1 | 2.3 | 48 | 9.8 | 577 | 1,020 | ||
| Infant D | 4 | 4 | 3.5 | 4 | NC | NC | NC | 0.04 | 0.000 | |
| Median, mothers | 975 | 2 | 7.8 | 48 | 14.1 | 3,225 | 4,510 | |||
| Median, infants | 22 | 2 | 2.4 | 8 | NC | 197 | 66 | 0.03 | 0.009 |
a
NC, not calculable; AUCT, total area under the time-concentration curve; I/M, infant/mother ratio.