TABLE 4.

Hypothetical i.v. dosage, corrected for plasma protein binding, of antibiotics needed to reach the in vitro concentrations tested in the present study

Antibiotic	Dose administered i.v.	Mean concn (mg/liter)	% protein binding	Hypothetical i.v. dose	Reference(s)
Cefamandole	1,000 g	Serum, 77.7; blister, 22.1 (peak)	74	Serum, 8 g for 50 mg/liter, 16 g for 100 mg/liter, 80 g for 500 mg/liter	Armstrong et al. (2), Fong et al. (17)
Fosfomycin	8 g (100 mg/kg)	Serum, 394.7 (peak); bone tissue, 96.4	Negligible	Serum, 2 g for 100 mg/liter, 6 g for 250 mg/liter, 24 g for 1,000 mg/liter; bone, 8 g for 100 mg/liter	Ode et al. (34), Schintler et al. (47)
Tigecycline	100 mg	Serum, 0.198; bone, 0.077; synovial fluid, 0.116 (after 4 h)	71-97	Serum, >7-10 g for 1 mg/liter, >35-50 g for 5 mg/liter; bone, >70-100 g for 1 mg/liter	Rodvold et al. (43)
Vancomycin	1 g	Plasma, 12.9; cancellous bone, 2.66; cortical bone, 11.53 (variable interval after dosing)	10-50	Serum, 0.5-1 g for 5 mg/liter, 12.5-10 g for 25 mg/liter; cancellous bone, 2-4 g for 5 mg/liter, 10-20 g for 25 mg/liter	Garazzino et al. (19)
Daptomycin	12 mg/kg	Serum, 164.8 (peak) and ca. 20 (trough)	90-93	Serum, 8 mg/kg for 5 mg/liter; 40 mg/kg for 25 mg/kg	Benvenuto et al. (3)