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Overview of trial design. Volunteers received three treatments in a sequence allocated randomly. Treatments: A, DRV/r 600/100 mg BID on days 1 to 12, with an additional morning dose on day 13; B, RFB 300 mg QD on days 1 to 13; C, DRV/r 600/100 mg BID on days 1 to 13 plus RFB 150 mg QOD from day 1 to 13.
