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Safety summary
| Event | Incidence, n (%) (n = 18 volunteers/treatment) |
||
|---|---|---|---|
| A (DRV/r) | B (RFB) | C (DRV/r + RFB) | |
| Any adverse event | 5 (28) | 8 (44) | 15 (83) |
| ≥1 serious adverse event | 0 | 2 (11) | 2 (11) |
| ≥1 grade 3 or 4 adverse event | 0 | 2 (11) | 3 (17) |
| ≥1 adverse event leading to permanent discontinuation of trial medication | 0 | 2 (11) | 5 (28) |
| Laboratory abnormalities | |||
| ≥1 worst grade 3 or 4 laboratory abnormality | 1 (6) | 9 (53) | 3 (17) |
| ≥1 laboratory abnormality leading to permanent discontinuation | 0 | 2 (11) | 0 |
