TABLE 1.
Activity of fusidic acid and five comparator agents tested against a comprehensive resistant challenge collection of 35 contemporary N. gonorrhoeae isolates
| Antimicrobial | No. of occurrences at indicated MIC (μg/ml) |
% for S isolates/% for R isolatesa | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.008 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | >4 | ||
| Fusidic acid | 12 | 17 | 5 | 1 | −/− (−/−) | |||||||
| Azithromycin | 1 | 15 | 12 | 5 | 1 | 1 | −/− (80.0/5.7) | |||||
| Ceftriaxone | 18 | 6 | 6 | 3 | 2 | 100.0/− (100.0/0.0) | ||||||
| Ciprofloxacin | 16 | 2 | 5 | 3 | 2 | 1 | 1 | 5 | 51.4/20.0 (51.4/48.6) | |||
| Penicillin | 1 | 4 | 3 | 2 | 4 | 5 | 6 | 4 | 6 | 22.9/45.7 (22.9/45.7) | ||
| Tetracycline | 6 | 2 | 8 | 7 | 7 | 1 | 4 | 22.9/34.3 (45.7/34.3) | ||||
a
Values representing CLSI criteria (5) for S (susceptible) and R (resistant) isolates are shown outside parentheses. Values representing EUCAST criteria (http://www.eucast.org/clinical_breakpoints/) are shown in parentheses. “−” indicates no interpretive criteria.