TABLE 2.
Activity of fusidic acid and four comparator agents tested against 10 C. trachomatis strains
| Antimicrobial | MIC (μg/ml)a |
MBC (μg/ml)b |
||
|---|---|---|---|---|
| Range | MIC90 | Range | MBC90 | |
| Fusidic acid | 0.12-0.5 | 0.5 | 0.12-0.5 | 0.5 |
| Azithromycin | 0.015-0.12 | 0.12 | 0.015-0.12 | 0.12 |
| Clarithromycin | 0.015-0.12 | 0.06 | 0.015-0.12 | 0.06 |
| Telithromycin | 0.015-0.25 | 0.06 | 0.015-0.25 | 0.06 |
| Doxycycline | 0.015-0.06 | 0.06 | 0.015-0.06 | 0.06 |
a
The MIC is defined as the lowest antimicrobial concentration at which no intracellular inclusions were observed.
b
The minimum bactericidal concentration (MBC) was defined as the lowest antimicrobial concentration that results in no observable inclusions after passage in cell culture.