FIG. 5.

Glycolipids require host innate and adapted immunity components to trigger protection against JEV infection. Seven-week-old immunodeficient mice lacking Stat-1 (A), immunoglobulin μ chain (B), or CD8 α chain (C) were administered compound C34 or 7DW8-5 or solvent, as described in the legend to Fig. 4, using a two-dose protocol. The Stat-1-knockout mice were intraperitoneally challenged with 0.1 PFU of JEV (RP-9 strain). The Ig μ chain-knockout and CD8 α chain-knockout mice were challenged as described in the legend to Fig. 4. The mice were monitored daily for 25 days. The percent survival is shown, and the number of mice in each experimental group is shown in the key to each panel.