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Activity of lersivirine against a panel of mutant RT enzymes and viruses. (A) Lersivirine and efavirenz were tested against a panel of mutant RT enzymes, and their respective fold difference versus wt RT was plotted. White bars, efavirenz; black bars, lersivirine. (B) xy plot of the log of the fold difference of the activity of lersivirine against mutant RTs versus the log of the activity of lersivirine against the corresponding mutant NL4-3 viruses.
