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Myostatin depletion reduced wheel-running distances (A and B). The effect was not accounted for by a slower running speed (C) but by a reduction in the time spent running (D) primarily because of fewer running bouts (E) rather than shorter bouts (F). Bars and circles represent means; whiskers represent standard errors. *Significant difference between control and myostatin-deficient mice (P < 0.05).
