Table 2.
Haplotypes of six Plasmodium falciparum harbouring mutant pfcrt detected in Andapa and Tsiroanomandidy
Study site | Number of isolates | pfCRT haplotypes | Codon sequences |
||||
---|---|---|---|---|---|---|---|
72 | 73 | 74 | 75 | 76 | |||
Tsiroanomandidy | 1 | CVMNK and CVIDTa | TGT | GTA | ATG/ATT | AAT/GAT | AAA/ACA |
Andapa | 2 | CVMNK and CVIDTa | TGT | GTA | ATG/ATT | AAT/GAT | AAA/ACA |
1 | CVMNK and CVIETa | TGT | GTA | ATG/ATT | AAT/GAA | AAA/ACA | |
2 | CVIET | TGT | GTA | ATT | GAA | ACA |
Haplotypes for mixed infections (wild/mutant) might be debated as suggestive, but sequencing confirmed the mutation of the 74 and 75 codons and also the occurrence of the key mutation K76T.