Table 1.
Apparent initial chloroquine efflux rates from various P. falciparum parasites in glucose-rich (Glu) or glucose-free medium (replaced by an equivalent amount of 2-deoxyglucose, 2DG), and in the presence and absence of 10 μM verapamil (Ver).
| Parasite | Glu |
2DG |
||
|---|---|---|---|---|
| −Ver (min−1) | +Ver (min−1) | −Ver (min−1) | +Ver (min−1) | |
| Dd2 (CQR) | 0.55 ± 0.06* (5) | 0.08 ± 0.01 (4) | 0.23 ± 0.03** (3) | 0.25 ± 0.03** (3) |
| HB3 (CQS) | 0.09 ± 0.04 (9) | 0.08 ± 0.01 (3) | 0.28 ± 0.02** (3) | 0.31 ± 0.03** (3) |
| N3D6 (CQS) | 0.04 ± 0.01 (3) | 0.07 ± 0.01 (3) | 0.34 ± 0.07** (3) | 0.36 ± 0.09** (3) |
The means ± SEM of n independent determinations are shown.
*
P < 0.01, with HB3 as a reference;
**
P < 0.01 between rates determined in the presence and absence of glucose.