Fig. 2.

Mutations in mouse Aspm reduce fertility in males and females. Frequency of occurrence of various litter sizes, expressed as percentage of all vaginal plug-positive copulations, for WT and 1-25 and 1-7 het and hom males (Left) and females (Right) paired with C57BL/6 females and males, respectively. Black columns indicate the percentage of females with no embryos (litter size = 0), gray columns the percentage of litters with embryos. Mean number of embryos in pregnant females is illustrated above the gray columns; horizontal error bars indicate SD. Data from (left, top to bottom) 74, 40, 55, 35, and 54 matings and (right, top to bottom) 45, 28, 26, 20, and 39 matings. *P < 0.05; **P < 0.01; ***P < 0.001.