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Representative fields from clinical muscle biopsy (from 2002) of the quadriceps muscle in a DMD manifesting carrier with 100% skewing of X chromosome inactivation (subject #8), and a control skeletal muscle. Immunohistochemical staining was performed under a clinical protocol using as a primary antibody Mab1645 (Chemicon), raised against a recombinant full-length protein. There is a mosaic pattern of dystrophin expression, but the majority of fibers do not express dystrophin.
