Skip to main content
. 2010 Sep 23;6(9):e1001137. doi: 10.1371/journal.pgen.1001137

Figure 3. Abnormal chromosome condensation and high incidence of aneuploidy in ATRX deficient oocytes.

Figure 3

(A) Chromosome spread from a control oocyte at the metaphase II stage showing prominent ATRX staining at pericentric heterochromatin (arrows). (B) Lack of ATRX staining at pericentric heterochromatin (thin arrow) is associated with abnormal chromosome condensation (bold arrows) and chromatid breaks (C, arrowhead). (D) In vivo matured transgenic ATRX-RNAi oocytes exhibit a high incidence of aneuploidy. Chromosome spread exhibiting a hyperploid karyotype of 20 chromosomes and an additional single chromatid (circled) is shown. Data are presented as the mean ± s.d. of three independent experiments. Scale bar  = 10 µm.