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. 2010 Sep 23;6(9):e1001137. doi: 10.1371/journal.pgen.1001137

Figure 6. Chromosome fragmentation in ATRX deficient oocytes during the transition to the first mitosis.

Figure 6

(A) Strontium chloride-activated control and (B) transgenic oocytes at late anaphase II stained with ATRX (red) and β-tubulin (green). Numerous chromosomal fragments (arrows) are evident in the transgenic oocyte. Asterisks indicate the position of the polar body. Scale bar  = 50 µm. (D) Transgenic oocyte with a multi-polar spindle (arrows, right image) and a control (C, left image). Scale bar  = 10 µm. (E) Proportion of artificially activated oocytes presenting chromosome fragmentation. Data are presented as the mean ± s.d. of three independent experiments.