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. 2010 Sep 23;6(9):e1001130. doi: 10.1371/journal.pgen.1001130

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Naj et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Plots depict expected versus observed −log10 P-values for 483,399 single SNP tests of association (in 931 LOAD cases and 1,104 cognitive controls, with adjustment for principal components as covariates for population substructure). Plot A includes the most-strongly associated SNPs within the APOE locus, whereas plot B excludes the three most-strongly associated SNPs for clarity.