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. 2010 Sep 23;6(9):e1001117. doi: 10.1371/journal.ppat.1001117

Figure 8. The comparative immunogenicity of HBZ and Tax.

Figure 8

(A) The predicted top binding peptide from Tax and HBZ to each of the 43 alleles for which Metaserver predicts binding affinities was found. Peptides from Tax are bound more strongly than peptides from HBZ (P = 0.00002, paired Wilcoxon-Mann-Whitney). Data pairs represent binding of the same allele to the two different proteins Tax and HBZ. (B) Consistent with this, the frequency of Tax-specific CD8+ T cells was also greater compared to HBZ-specific CD8+ T cells in the 45 HTLV-1 infected individuals tested using IFN-γ ELISpot (P = 0.000006, paired Wilcoxon-Mann-Whitney). Data pairs represent frequency of the response in the same individual to the two different proteins Tax and HBZ.