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. 2010 Sep 23;6(9):e1001120. doi: 10.1371/journal.ppat.1001120

Figure 1. TcpC acts as a virulence factor by promoting bacterial persistence in the urinary tract and abscess formation in the kidneys of wild type mice.

Figure 1

(A) Bacterial counts (CFUs) in kidneys of C57BL/6, Tlr4−/− and Myd88−/− on days 4 and 7 post-infection. (B) Bacterial counts (CFUs) in urine of C57BL/6, Tlr4−/− and Myd88−/− mice after infection with CFT073 or ΔTcpC. (C) MIP-2 response kinetics in urine samples of wt and mutant mice. (D) Neutrophil response kinetics in urine samples of wt and mutant mice. P values (*p<0.05, **p<0.01 and ***p<0.001 for CFT073 versus ΔTcpC mutant and for wt versus mutant mice; Fisher's exact test). Eight to ten mice were used per time point. (E) Abscess formation (arrows) in the kidneys of wt mice infected with CFT073 but not in Tlr4−/− and Myd88−/− mice infected with CFT073 or ΔTcpC (Scale bar, 2 mm).(F) Abscess formation after CFT073 or ΔTcpC infection, in percent of the total number of kidneys examined.