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. 2010 Sep 23;6(9):e1001120. doi: 10.1371/journal.ppat.1001120

Figure 7. Effects of TcpC virulence in Trif −/− and Trif Lps2/Lps2 mice infected with CFT073 or ΔTcpC.

Figure 7

(A) Bacterial burden (CFU) in kidneys of wt (C57BL6/129), Trif −/−, wt (C57BL/6) and Trif Lps2/Lps2 mice on day seven after infection with CFT073 or ΔTcpC. (B) Bacterial numbers in urine of wt and mutant mice after infection. (C) Kinetics of the MIP-2 response, measured in urine samples. (D) Neutrophil response kinetics in urine of wt and mutant mice. P values (*p<0.05, **p<0.01 and ***p<0.001 for CFT073 versus ΔTcpC mutant and for wt versus mutant mice; Fisher's exact test; ns = not significant). (E) Abscess formation in mouse kidneys, seven days post-infection (Scale bar, 2 mm). (F) Abscess formation after CFT073 or ΔTcpC infection, in percent of the total number of kidneys examined.