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. 2010 Sep 23;6(9):e1001121. doi: 10.1371/journal.ppat.1001121

Figure 8. Model of GP-dependent EBOV cell entry.

Figure 8

For EBOV cell entry, the binding of GP to cellular receptor(s) may activate cellular actin modulators (PI3K, small GTPases, PKC and Pak1), which trigger the actin-dependent membrane ruffling that leads to macropinocytosis. The virions are then internalized via macropinocytosis. Macropinosomes containing the virions are eventually fused to Rab7-positive late endosomes/lysosome (late maturation), resulting in the fusion of the viral envelope with the endosomal membrane in a low pH- and cathepsin-dependent manner.