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. 2010 Sep 23;5(9):e12974. doi: 10.1371/journal.pone.0012974

Figure 1. Age-related effects of BACE1+/− deletion on memory deficits in 5XFAD mice.

Figure 1

Memory function of mice at 6 months (A, C) and 15–18 months (B, D) of age was tested using the spontaneous alternation Y-maze task. (A, B) Spatial working memory, as assessed by the spontaneous alternation performance, is significantly impaired (around 50% chance levels) in 5XFAD mice irrespective of age compared to wild-type controls (* p<0.05). Note that BACE1+/−·5XFAD are rescued completely back to wild-type levels of alternation performance at 6 months but not at 15–18 months of age (# p<0.05 versus age-matched 5XFAD). n = 5–12 mice per group. (C, D) Total number of arm entries reflecting exploratory activities of mice in the Y-maze does not differ between the four groups irrespective of age. n = 5–12 mice per group. All data are presented as mean ± SEM.