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. 2010 Jul 1;12(4):R126. doi: 10.1186/ar3064

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Copyright ©2010 Helmark et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intraarticular (top row) and peri-synovial (bottom row) concentrations of COMP and Aggrecan. Each point represents a mean of the measured values and each connecting line represents a subject with before/after values. COMP remained stationary in the NEx group in both compartments and in the Ex group peri-synovially over time, but decreased in the Ex group intraarticularly, whereas Aggrecan concentrations decreased significantly from T1 to T2 in both positions regardless of exercise (*P < 0.05).